GETTING MY SIKIK TO WORK

The functionality of SIK1 in tumorigenesis. SIK1 is usually a tumor suppressor gene, which plays an important regulatory part in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and impacts cancer cell proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 can also promote canc